NAD+ 500MG
NAD⁺ is a coenzyme present in all living cells, playing a central role in redox reactions, energy metabolism, DNA repair, and cellular signaling. This high-purity NAD⁺ solution is designed for laboratory research involving aging, mitochondrial function, and sirtuin activation pathways. Not for human use or therapeutic application.
Product Overview:
Product Name: NAD⁺ (Nicotinamide Adenine Dinucleotide)Quantity: 500mgMolecular Formula: C21H27N7O14P2Molecular Weight: 663.43 g/molResearch Use Only. Not for Human Consumption.
Research Applications:
Mitochondrial Function and Energy Metabolism
NAD⁺ is an essential redox cofactor in mitochondrial energy production, particularly in oxidative phosphorylation. It shuttles electrons from glycolysis and the TCA cycle to the electron transport chain, enabling ATP generation . Research using NAD⁺ focuses on its role in mitochondrial bioenergetics and cellular adaptation under energetic stress.
Depletion of NAD⁺ levels is frequently observed in aged or metabolically stressed cells, making it a target in studies of mitochondrial dysfunction, senescence, and metabolic disorders.
Sirtuin Activation and Epigenetic Regulation
NAD⁺ is a required co-substrate for sirtuin deacetylases (SIRT1–SIRT7), which are involved in DNA repair, chromatin remodeling, and gene expression . These enzymes regulate cellular longevity, inflammation, and metabolic adaptation, making NAD⁺ supplementation a critical variable in aging and epigenetic studies.
Studies often explore how NAD⁺ influences SIRT1-mediated pathways to improve DNA stability, reduce histone acetylation, and modulate transcriptional activity under stress conditions.
DNA Repair and PARP Function
NAD⁺ is also a substrate for poly(ADP-ribose) polymerases (PARPs), which mediate DNA damage response and repair mechanisms. When DNA strand breaks occur, PARP enzymes consume NAD⁺ to signal for repair machinery, especially under oxidative stress or genotoxic insult .
In research models, excessive PARP activation can lead to NAD⁺ depletion and subsequent ATP loss, contributing to cell death. Thus, NAD⁺ is studied in contexts of genomic stability, neurodegeneration, and cell survival signaling.
Immunometabolism and Inflammatory Regulation
Recent research links NAD⁺ to immune cell regulation, particularly via CD38 and SIRT1 pathways in macrophages and T-cells. NAD⁺ modulates pro-inflammatory cytokine expression and T-cell function, making it a point of interest in immunometabolic research .
Studies are exploring how NAD⁺ levels influence cellular redox states and inflammatory gene transcription, especially in chronic inflammatory or autoimmune models.
Referenced Citations:
Ying W. “NAD⁺ and NADH in cellular metabolism.” PubMed
Source: Antioxidants & Redox Signaling – Fundamental review on redox roles of NAD⁺.
Imai S, Guarente L. “NAD⁺ and sirtuins in aging.” PubMed
Source: Trends in Cell Biology – NAD⁺ as a cofactor for SIRT enzymes.
Bai P, et al. “PARP enzymes and NAD⁺ depletion in DNA damage.” PubMed
Source: Molecular Cell – PARP-mediated NAD⁺ use in genomic repair.
Chini EN, et al. “CD38/NAD⁺ axis in inflammation and immunity.” PubMed
Source: Cell Metabolism – NAD⁺ in immunological and inflammatory signaling.
Pepcore products are intended only for laboratory research and in vitro experiments (outside a living body). They are not intended for diagnostic, therapeutic, clinical, veterinary, or any in vivo use. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
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